University of Maryland Surgeon Scientist Awarded Grant for Graft, Angioplasty and Stent Failure Research


The 2013 Wylie Scholar grant was awarded to support Dr. Thomas Monahan's research identifying the mechanisms responsible for vein graft, angioplasty, and stent failure. Dr. Monahan studies the body's reaction to surgery known as intimal hyperplasia, or the reduction of vessel diameter that ultimately limits the long term success of all cardiovascular reconstructions. Dr. Monahan has identified a protein, MARCKS, that when knocked down, inhibits smooth muscle cell migration and proliferation. This protein is potentially a powerful target for the prevention of this common complication.

"Support from the Wylie Scholarship has allowed me the freedom to pursue MARCKS as a potential target for therapy to prevent intimal hyperplasia. This support is especially valuable in the very competitive present funding environment. This funding will allow me to generate data and transition to an independently funded surgeon-scientist," explains Dr. Monahan. Learn more about Dr. Monahan's work here.


University of Michigan Surgeon Scientist Awarded Grant for Diabetic Wound Healing Research

katherine_gallagher_mdDiabetic wounds represent a significant health problem and are currently the leading cause of non-traumatic amputation in the United States. In an effort to address this problem, Dr. Gallagher is studying impaired wound healing in diabetes in order to design novel therapeutic agents for the treatment of these wounds. Currently, her laboratory is evaluating the role of inflammation and immune cell function in diabetic wounds. The impaired wound healing seen in diabetes is likely multifactorial, due to both alterations in the peripheral tissue and systemic alterations in the bone marrow. Stem cells from the bone marrow play a key role in wound healing. Her lab focuses on determining the molecular changes in these cells in diabetic patients and how this influences wound healing. Determining these alterations in stem cell populations in diabetics, will allow for development of immune therapies targeting specific proteins involved in this process. Learn more about Dr. Gallagher here.


First Genetic Marker Identified to Predict PAD Treatment Failures

Vascular Cures develops Next Generation TreatmentsHundreds of thousands of procedures are performed each year in the U.S. to improve leg circulation in patients suffering from peripheral artery disease (PAD), yet up to half of these fail within a few years due to excessive scarring that leads to reduced blood flow. Members of Vascular Cures Research Network, Michael S. Conte, MD and Alexander Clowes, MD, discovered that the gene p27 may be involved. The results of their study were presented at the Society for Vascular Surgery Annual Meeting. Find out more.


University of Washington Surgeon Scientist Awarded Grant for Blood Vessel Research

gale_tang-smaller-resizedVascular Cures named Gale Tang, MD, the 2011 Wylie Scholar in Academic Surgery. The $150,000 three-year grant was award to support Dr. Tang's genetic research into understanding how blood vessels grow in order to prevent amputation for people suffering from the most advanced stage of peripheral artery disease (PAD).  

PAD develops when arteries in the lower limbs become clogged with fatty deposits that limit blood flow. Advanced stages of the disease can lead to critical limb ischemia (CLI), resulting in painful sores, gangrene, and limb amputation. Each year CLI results in over 100,000 amputations in the United States. Up to 25% of patients with CLI die within the first year. Learn more about Dr. Tang's research...


Wylie Scholar Wins Prestigious Lister Prize

Barry Rubin, MD, PhDThe University of Toronto awarded Vascular Cures' Wylie Scholar Barry Rubin, MD, PhD, the Lister Prize in Surgery – their highest research award. The Lister Prize is given to an investigator who has shown outstanding and continuing productivity of international stature as evidenced by research publications, grants held, students trained, and other evidence of stature of the work produced.

Read more in The Surgical Spotlight, a University of Toronto publication...


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